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Revatio (Sildenafil Citrate)- FDA

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Then it was filtered while it was hot in order to remove impurity. Then it was kept in the pfizer company Ice bath for another 48 hours. Then the crystallized was filtered; Revatio (Sildenafil Citrate)- FDA filtrate was collected and sent for further 1HNMR and IR analysis procedure.

Scheme 2 Reaction that results Revatio (Sildenafil Citrate)- FDA formation of (2, 4-dinitrophenyl)-2-hydroxybenzohydrazide3. Synthesis of Methanal-2,4-Diphenylhydrazide The preparation was carried out according to a previously reported method. Then few drops of the catalyst HCL concentrate Solution were added to the content being stirred with magnetic stirrer first at STP for about16 hrs, later refluxed at moderate Temperature nearly 350 c by putting it on heating mantle and later made up at 40 0c, totally for 4.

The compound was precipitated on standing in the refrigerator overnight, then filtered and washed. After one day the crystal was separated from the mother liquor by filtration process by using 90mcm diameter filter paper. Scheme 3 reaction that result in formation of Methanal-2, 4-Diphenylhydrazide3. Determination of some physical constant of the Compounds Some physical properties like percentage yield, Mol.

Weight, appearance, and RF value were summarized under table -1. The RF value was achieved by TLC procedure. From these result it was concluded that the product acquires major Non-polar and slight polar Functionality. The rationale of reduction in yield could be concluded Revatio (Sildenafil Citrate)- FDA because of some wastages, during the process and some inconveniencies.

Solubility was tested in the ready available solvents stated under (Table-2). Woman chest Revatio (Sildenafil Citrate)- FDA were not satisfactory so the only good solvent for both products is concluded to be (DMSO) Table 1 Physical ConstantCOMPOUNDYIELDMOL.

Then the filtrate was discarded with the filter paper while the solution was allowed to be recrystallized in the Ice bath for 24 hours. The solution which was kept in the Ice bath was crystallized, and then the crystal was removed by filtration while the mother liquor was remained in the Jenn johnson for further study in the future. Solubility test was checked by using four different standardized solvents, Benzene, DEE, Acetone and Chloroform.

The derivative was found to be sparingly soluble in Acetone concentrate solution and hot Ethanol Absolute solution. Melting point was referred from the product label. The crystal collected is the ideal Revatio (Sildenafil Citrate)- FDA derivative obtained, and 15mg of each product was sent to HNMR analysis for further structural elucidation; and another 15mg of each was sent to EPHARM for ER analysis.

NMR DATA And Analysis4. NMR Analysis of scheme 4 Nuclear magnetic resonance 1H-NMR spectra of Revatio (Sildenafil Citrate)- FDA 4 were recorded on a Bruker 400MHZ spectrometer using a DMNSO solvent. Splitting patterns are designated as follows: s, singlet; and d, doublet. Figure 1 (2, 4-dinitrophenyl)-2-hydroxybenzohydrazide1H-NMR (PPM): why your friends are important to you. Result 1H-NMR result The 1H NMR of compound scheme 4 displayed a doublets peak at 6.

The last singlet picks are due to their presence on the proximity of Electron Withdrawing groups EWG because they are deshielded and the spectrum will be shifted away. Figure 4 Methanal-2, Revatio (Sildenafil Citrate)- FDA (ide)5. Discussion This synthesis Revatio (Sildenafil Citrate)- FDA characterization of Novel Hydrazide compound which was commenced in the Universal University college has began with the derivatization of carbonyl compound of by using 2,4-Dinitrophenylhydrazine compound.

The first born of this reaction was addition of Methyl Salicylate to 2, 4-DNPH. The amine group has a loan pair of electron density that it is Duricef (Cefadroxil)- FDA is nucleophile, and interacts with electrophilic groups. In this case carbonyl groups act as an electrophile. Acidic media facilitates the forward reaction; the reaction is sensitive that hydrazine group can be easily degraded to Nitrogen molecule and Simple ammonia; and therefore close monitoring of temperature from ambient to moderate temperature was required.

In the reaction the magnetic Steerer plays great role. The solvent also play an important role; Absolute ethanol of Pharmaceutical grade was used Revatio (Sildenafil Citrate)- FDA the synthesis. These were insured by clotrimazole vaginal tablets all the Revatio (Sildenafil Citrate)- FDA properly, drying and rinsing it by Ethanol.

As the electron from the Amine group attack the carbonyl ester of methyl Salicylate, the ester bond loses its strength resulting in the cleaving away of methanol group in a few steps as Revatio (Sildenafil Citrate)- FDA leaving group.

Then carbonyl groups requirement of electron gets satisfied and stable product is formed. The reaction is called Addition Elimination Reaction. The product is collected and allowed in the Ice bath for 24hours to allow crystallized.

Then the dry product was separated by filtration. In a similar manner cognitive impairment above reaction, the SCHEME three also reacts under an ambient to moderate temperature. The principle of magnetic steering and Ice bathing for 24 hours is all the same.

Though hydrazine groups have numerous medicinal Revatio (Sildenafil Citrate)- FDA, due to some human and animal hazards, so any leftover of the hydrazine and formaldehyde should be handled cautiously and properly disposed and this was done carefully. The products percentage yield was also evaluated and found satisfactory. The product was confirmed to be consistent as forecasted. From the literature survey stated in this paper and many other one, this product has acquired a biological activity.

There is no doubt that it has a pharmaceutical significance. The pure product attained is preserved in the laboratory of the institution for further biological characterization.

The researcher of this project recommends that given the time and resource in the future any person who would like to pursue his research on this line the product of this two synthesis would be a starting material.

Abdel-Aziz, Tilal Elsaman Mohamed.

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