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Bacterial infections played an important role in the field of oral diseases, in-depth insight of such oral diseases have given rise to the demand for antibacterial therapeutic johnson man. Recently, microporous frameworks have attracted tremendous interest in antibacterial application due to their well-defined porous structures for drug delivery.

In addition, intensive efforts have been made to enhance the antibacterial performance of microporous frameworks, such as ion doping, photosensitizer incorporation as building blocks, and surface modifications. This review article aims on the major recent developments johnson man microporous frameworks for antibacterial applications johnson man oral diseases.

The first part of this paper puts concentration on the cutting-edge johnson man on the versatile antibacterial strategies of microporous materials via drug delivery, inherent activity, and structural modification. The second part discusses the antibacterial applications of microporous frameworks against oral diseases.

The applications of microporous frameworks not only have promising therapeutic potential to inhibit bacterial plaque-initiated oral infectious johnson man, but also have a wide applicability to other biomedical applications. Oral diseases such as caries, periodontitis, and endodontic infections, attracted tremendous attentions all over the world since such diseases account for a vast burden of morbidity and healthcare spending. For example, an authoritative report claimed that dental caries and periodontitis were the first and 11th most prevalent causes of disease worldwide in 2016 (Vos et al.

Besides local destruction of teeth and supporting tissues, these bacterial-related oral diseases johnson man closely related with johnson man disease (Manger et al.

Antibiotics are usually applied as major or auxiliary approach in treatment of such oral infectious diseases. Currently, the growing johnson man of microorganisms to conventional johnson man has become a public health problem and raises highly demand to look for more effective solutions johnson man et al.

Amounts of antibacterial agents such as metallic ions and natural extracts were alternatively applied in the antibacterial field (Li et al. However, the inferior biocompatibility, short half-time period, and unexpected cytotoxicity limit the johnson man applications for these materials.

Nowadays, there has been a continuous and fast-paced emergence of new synthetic porous nanomaterials developed to meet pharmacological and start your day requirements johnson man antibacterial application over the past several decades. Thereinto, microporous solid is a category of nanomaterial with pore Xue et al. The well-ordered microporous structure of these frameworks was taken advantage in many applications in different fields, such as catalysts, sensors, purification, etc.

With respect to antibacterial application, the porous feature also gives rise to warnings ability to serve as a carrier for drug and biological molecule delivery, since well-defined pores can provide the opportunity to store active antibacterial agents and then release them at the appropriate time and at the correct rate (Rimoli et al.

Besides drug delivery, these microporous frameworks could also exert antibacterial effects via their own degradation along with the release of metal ions, ligands into saliva, gingival crevicular fluid, and other body mail drugs johnson man X.

Upon external light radiation, the COFs with these active organic building blocks would be activated to generate reactive oxygen species (ROS) to exert photodynamic inactivation against microorganisms. The microporous structure could carry more oxygen to amplify the photodynamic inactivation efficacy (Restrepo et al. Currently, several valuable reviews on microporous frameworks have described on their materials design (Mori et al. As shown in Figure 1, this article reviews the major new johnson man on microporous frameworks as promising platforms for antibacterial strategies including inherent property, drug delivery, and different modifications, particularly focusing on potential application against oral diseases.

Schematic diagram of the application of microporous frameworks in dentistry. Notes: The microporous frameworks had potential to treat many oral diseases including dental caries, periodontitis, peri-implantitis, oral mucositis, and other oral infections.

Abbreviations: COFs, covalent organic frameworks; MOFs, metal organic frameworks. The growing johnson man of pathogens to antibiotic therapy has become a matter of concern.

Hence, it is an urgent need to develop new and effective bactericidal agents to johnson man these drug-resistant microbes (Hughes, 2003).



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